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MITOCHONDRIAL GENOMES
Organization
Gene content is highly
conserved in the mitochondrial genome of animals, but
rearrangements, especially in the position of tRNA genes,
do occur. The COI gene is ordinarily flanked on its 5'
terminus by tRNATyr and at its 3' terminus by tRNALeu.
The order of protein coding genes is also highly conserved.
MtGenome data on over 250 metazoan species suggests relatively
few major gene re-arrangements (data is available from
the Organellar Genome Retrieval [OGRe]
project). In most animals, the COI gene is positioned
between two other protein coding genes - ND2 on its 5'
flank and COII on its 3' flank.
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